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Effects beyond this timeframe remain unknown
In patients with heart failure with preserved ejection fraction (HFpEF) and obesity, semaglutide decreased heart failure-related symptoms and improved quality of life in patients with or without type 2 diabetes (STEP-HFpEF [4] and STEP-HFpEF DM [5] trials), however, the studies did not provide evidence regarding cardiovascular outcomes
It tends to be well tolerated and easily permeates the skin
Practical approaches include staying at a given dose for longer than the minimum four weeks if weight is dropping rapidly
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