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Yes, typical protocols suggest starting at 200 mcg daily and gradually increasing the dose by about 200 mcg every two weeks, as tolerated, up to a maximum of 600 mcg daily
Food, environment, lifestyle and gut function may all influence gene expression, inflammation, mitochondrial function and methylation without changing the DNA sequence
Journal of Affective Disorders
Betaine supplementation has been used for over 40 years to support individuals with genetic defects of folate dependent remethylation because betaine is known to increase methionine concentration and aid homocysteine reduction
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