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Inflammation and Cardiovascular Benefits Triple agonists are being studied for additional benefits including: reduced inflammation lower triglycerides improved cholesterol markers reduced cardiovascular risk factors Stronger Metabolic Shift The deeper the metabolic improvement, the more sustainable the long-term weight management
Pregnant or breastfeeding women should not use it due to limited safety data
A Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023) reported that participants receiving higher doses of retatrutide (up to 12 mg) achieved mean body weight reductions of approximately 1724% over 48 weeks
Pushing the plunger too fast increases discomfort and can cause leakage
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