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Diagnostic evaluation may include: Detailed neurological examination assessing sensation, reflexes, and motor function Hemoglobin A1c measurement to evaluate recent glycemic control Vitamin B12 levels and methylmalonic acid (if B12 is borderline) Serum protein electrophoresis (SPEP) and immunofixation to screen for paraproteinemia Thyroid function tests, as hypothyroidism can contribute to neuropathic symptoms Comprehensive metabolic panel to assess renal and hepatic function Nerve conduction studies in selected cases with atypical features Management strategies focus on optimizing glycemic control, which remains the most evidence-based intervention for preventing and potentially improving diabetic neuropathy
KPV is a tripeptide fragment of alpha-melanocyte stimulating hormone
But heres the thing: women with PCOS often have a weaker GLP-1 response due to higher body fat, low muscle mass, and hormonal imbalances
Fourth, as the clinical data in this study was collected in 2017, semaglutide had not yet been available at that time
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