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(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

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Periodontitis-associated salivary microbiota exacerbates colitis and anxiety in mice via gut dysbiosis and found altered metabolism of histidine in the gut and brain (Qian et al., 2023)

It's important to note that some medications and treatments, such as glutathione injections, may cause temporary numbness as a side effect