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6.5.2 Oral semaglutide in established T2D (mean disease duration: 79 years) In patients with T2D uncontrolled on metformin (PIONEER 2), oral semaglutide (14 mg) provided significantly greater reductions in HbA 1c versus empagliflozin (25 mg) at Week 26 (1.3% vs 0.9%

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proposed that exenatide upregulates uncoupling protein-3 (UCP-3) and nuclear respiratory factor-1 (Nrf-1) in cardiomyocytes subjected to ischemia/reperfusion (I/R) via the cAMP/PKA pathway, thereby facilitating mitochondrial homeostasis [93]

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