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It signals the pancreas to release insulin, tells the liver to reduce glucose production, slows how fast food moves through your stomach, and communicates with your brain to reduce hunger

Adverse Reactions/Side Effects The following serious adverse reactions are described below or elsewhere in the prescribing information: Risk of Thyroid C-cell Tumors [see Warnings and Precautions (5.1)] Acute Pancreatitis [see Warnings and Precautions (5.2)] Acute Gallbladder Disease [see Warnings and Precautions (5.3)] Hypoglycemia [see Warnings and Precautions (5.4)] Acute Kidney Injury Due to Volume Depletion [see Warnings and Precautions (5.5)] Severe Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.6)] Hypersensitivity Reactions [see Warnings and Precautions (5.7)] Diabetic Retinopathy Complications in Patients with Type 2 Diabetes [see Warnings and Precautions (5.8)] Heart Rate Increase [see Warnings and Precautions (5.9)] Pulmonary Aspiration During General Anesthesia or Deep Sedation [see Warnings and Precautions (5.10)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice

Metformin remains widely used due to its affordability and long safety record

Emergence shapes the structure of the seed microbiota