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Hazen explains that it all goes back to the Great Depression, when food shortages led people to experience health issues related to nutritional deficiencies including pellagra, aka niacin deficiency
doi: 10.1089/jmf.2020.4751 252 NakamuraSTakahiraKTanabeG MorikawaTSakanoMNinomiyaKYoshikawaMet al
The first category includes NADs that target nucleic acids to regulate protein expression by promoting or inhibiting translation
A biomarker effect without a clinical one, as seen in EVOKE, is exactly the dissociation that should make researchers cautious about surrogate measures
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