Progress photos Take front, side, and back photos in the same lighting, same clothing, same time of day, every two weeks
Triple Agonist Mechanism: GIP, GLP-1, and Glucagon To appreciate why retatrutide has generated such intense scientific interest, it helps to look at each of the three receptors it targets and how they integrate in metabolic signaling
Niazi explains that tirzepatide is a newer dual-agonist that targets both the GLP-1 receptor and the GIP (glucose-dependent insulinotropic polypeptide) receptor, which he says offers superior metabolic regulation and appetite suppression. Mounjaro is currently FDA-approved for type 2 diabetes, and Zepbound is also FDA-approved for weight loss
In pancreatic -cells, the major bioactive hormone is glucagon that is formed by cleaved by Proprotein Convertase Subtilisin/Kexin Type 2 (PCSK2/PC2)