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We found microbial changes consistent with this phenomenon in reprogramming: the few genera of bacteria able to synthesize B 12 (~20 genera) 25 were generally enriched in OSKM mice after 7 days of doxycycline, with Proteus , Escherichia and Salmonella being most significantly enriched among the B 12 synthesizers (Extended Data Fig

B Complex Vitamins B vitamins support many cellular processes related to energy production and normal metabolic function

Given the clinical evidence reviewed above, patients with type 2 diabetes and/or obesity are the most promising candidate population to benefit from GLP-1RA-centered pharmacotherapy to improve cardiovascular and kidney outcomes

Hypothetical patient for demonstrative purposes only