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[15] It is approved as an antimanic and antiseizure in Japan as well

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Moreover, GLP-1RAs stimulate endothelial VEGF expression, a fundamental trigger for angiogenesis, leading to activation of downstream VEGF receptors (VEGFR-2), which initiate angiogenic cascades involving phospholipase C gamma/extracellular signal-regulated kinase/phosphoinositide 3-kinase/protein kinase B pathways