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Conversely, bile acids also affect the gut microbiota through activation of the innate immune system and production of antimicrobial peptides (127)
Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]
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One small study in 13 patients of glutathione 600mg daily for 10 days found increased glutathione levels in the nasal mucosa accompanied by improvements in nasal obstruction, rhinorrhea, and ear fullness
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